Using warfarin together with sulfamethoxazole may increase the risk of bleeding, especially if you are elderly or have kidney or liver impairment. You may need more frequent monitoring of your prothrombin time or INR by your doctor to safely use both medications.
Does Bactrim thin your blood?
Drug interactions of Bactrim include warfarin, because Bactrim enhances its blood-thinning effects, possibly leading to bleeding. Sulfonamides such as sulfamethoxazole can add to the kidney damage caused by cyclosporines.
What antibiotics are safe to use with warfarin?
THE BOTTOM LINE When prescribing antibiotics for patients taking warfarin, try to choose agents with a lower likelihood of affecting INR such as penicillin G, clindamycin, and 1st- and 4th-generation cephalosporins.
What medications should not be taken with Bactrim?
Table 4: Drug Interactions with BACTRIM
| Drug(s) | Recommendation |
|---|---|
| Methotrexate | Avoid concurrent use |
| Cyclosporine | Avoid concurrent use |
| Digoxin | Monitor serum digoxin levels |
| Indomethacin | Avoid concurrent use |
Why does bactrim interact with warfarin?
Bactrim inhibits CYP 2C9; which you remember is responsible for breaking down the more potent S-isomer of warfarin. Bactrim also inhibits CYP 3A4; which you remember is responsible for breaking down the less potent R-isomer of warfarin.
What drugs should not be taken with warfarin?
Common drugs that can interact with warfarin include:
- Aspirin or aspirin-containing products.
- Acetaminophen (Tylenol, others) or acetaminophen-containing products.
- Antacids or laxatives.
- Many antibiotics.
- Antifungal medications, such as fluconazole (Diflucan)
- Cold or allergy medicines.
Is 3 days of Bactrim enough for UTI?
Sulfamethoxazole/trimethoprim (Bactrim) is a first choice because it works very well and can treat a UTI in as little as 3 days when taken twice a day. Some providers might choose to have you take it a few days longer than that to be sure your infection is totally gone.
What antibiotic does not interfere with warfarin?
Conversely, cephalexin and clindamycin are believed to have only minimal interactions with warfarin. Prior studies have demonstrated that warfarin users are commonly prescribed antibiotics with known interactions.
Can I take antibiotics with blood thinners?
It is well-established that antibiotics can interact with warfarin. That is because, generally speaking, blood thinners work by blocking the effect of vitamin K in the gut. Antibiotics, for their part, interfere with the bacteria in the gut that make vitamin K.
Are there any drug interactions with warfarin oral?
All generic drug interactions for warfarin oral (lists will include brand and generic names): sulfamethoxazole-trimethoprim oral and warfarin oral. sulfamethoxazole-trimethoprim oral increases effects of warfarin oral by slowing drug metabolism.
What does Bactrim do to your body when you take warfarin?
Bactrim also inhibits CYP 3A4; which you remember is responsible for breaking down the less potent R-isomer of warfarin. Bactrim can also (somewhat) disrupt the normal flora in the gut; which you remember is responsible for breaking down and getting vitamin K into your body.
How does sulfamethoxazole-trimethoprim work with warfarin?
Serious – Use AlternativePotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed. sulfamethoxazole-trimethoprim oral increases effects of warfarin oral by slowing drug metabolism.
How does Bactrim DS interact with other medications?
Does BACTRIM DS Interact with other Medications? These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.
